Leiden University Medical Center (LUMC)

PIs LUMC: Eelco de Koning, Marten Engelse, Fran├žoise Carlotti

About the LUMC

The Leiden University Medical Center has a long tradition in diabetic research. Major research groups focus on metabolic health (Dept. of Endocrinology), transplantation (Dept, of Nephrology and Dept. of Surgery), autoimmunity in diabetes (Dept. of Immunohematlogy and Blood Transfusion) and complications (Dept. of Cardiology, Dept. of Nephrology, Dept. of Endocrinology). 

Relationship with DCTI

The LUMC is the main center for beta-cell transplantation in the Netherlands. The first pancreas transplantation was performed in the Netherlands in Leiden in 1984. The LUMC is one of the largest pancreas transplantation centers in Europe with 20-30 pancreas transplantations per year. In 2007 an islet isolation and transplantation unit was started and currently the LUMC is the only center in the Netherlands for isolation of pancreatic islets from donor pancreas and subsequent transplantation in patients with type 1 diabetes. Research programs have been developed around the islet isolation program. A major goal of the LUMC in the DCTI consortium is to optimize the islet isolation procedure so that more islets of higher quality will be available for transplantation. Improvements in pancreas preservation (in collaboration with the UMCG) and islet isolation procedures should lead to achieving this goal. Furthermore, tissue available for research generated in the LUMC will be used in the research programs of DCTI.