PI Xpand: Ruud Das

About Xpand

Xpand Biotechnology is a Dutch research and development-oriented SME that was founded in 2004 as a spin-off from the University of Twente, The Netherlands. The mission of Xpand Biotechnology is to become a key player in regenerative medicine by developing innovative bioreactor technology for the expansion of adherent (mesenchymal stem) cells. These cells can be used in regenerative medicine for the reconstruction, augmentation or replacement of various tissues and/or tissue functions, which will ultimately improve the patient’s quality of life. Xpand Biotechnology’s objective to reach this goal is to develop an automated decentralized bioreactor system (closed system device placed at the hospital) with which living autologous adherent cells (such as bone marrow derived mesenchymal stem cells) can be culture-expanded from a tissue biopsy such as a bone marrow aspirate. The laboratories available to Xpand Biotechnology are fully equipped to cover every aspect of regenerative medicine research, including tissue engineering, in vitro biological testing and bioreactor technology. Xpand Biotechnology has an ISO9001 and ISO13485 accredited quality system, GMP facilities and a clean room to produce clinical products. Xpand Biotechnology owns several patents related to regenerative medicine.

Relationship with DCTI

Within the DCTI consortium, Xpand provides production of cells that can serve as a potential alternative source of beta cells (duct-derived precursor cells) or as supporting cells for islets in the islet cells replacement device (ICRD). Xpand Biotechnology possesses bioreactor technology to create highly controlled and reproducible culture conditions and prime duct cells to obtain a beta cell phenotype after the expansion phase. Additionally, Xpand will provide expansion of mesenchymal stem cells that can be used as support cells in the ICRD. The bioreactor technology allows for closed system production of cells under a controlled environment (temperature, oxygen tension and pH), which will comply with GMP guidelines.